Forkhead transcription factors regulate mosquito reproduction
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چکیده
منابع مشابه
SnapShot: Forkhead Transcription Factors II
FOXM1 (12p13.33) GLI1, doxorubicin, NRAS, fulvestrant, butyric acid, FGF7, CDKN1A, YY1, MSA, vitamin D3, TNFSF11, IL6, CDC2 CDC25B, CENPA, AURKB, CCNA2, CCNF, CENPB, BIRC5, CCNB1, CDKN1A, ESR1, ADAM17, GLB1 Controls progression into S phase; regulates genes required for mitotic entry; liver development. Reduced hepatoblast and cardiomyocyte mitosis, ventricular hypoplasia. Die perinatally. Upre...
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The NAD-dependent deacetylase SIR2 and the forkhead transcription factor DAF-16 regulate lifespan in model organisms, such as yeast and C. elegans. Here we show that the mammalian SIR2 ortholog SIRT1 deacetylates and represses the activity of the forkhead transcription factor Foxo3a and other mammalian forkhead factors. This regulation appears to be in the opposite direction from the genetic in...
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Life expectancy of individuals in both developed and undeveloped nations continues to rise at an unprecedented rate. Coupled to this increase in longevity for individuals is the rise in the incidence of chronic neurodegenerative disorders that includes Alzheimer's disease (AD). Currently, almost ten percent of the population over the age of 65 suffers from AD, a disorder that is presently witho...
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Diabetes is a chronic metabolic disorder, characterized by hyperglycemia resulting from insulin deficiency and/or insulin resistance. Recent evidence suggests that high levels of reactive oxygen species (ROS) and subsequent oxidative stress are key contributors in the development of diabetic complications. The FOXO family of forkhead transcription factors including FOXO1, FOXO3, FOXO4, and FOXO...
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Transcription factors are modular proteins where distinct functions, such as DNA binding, trans-activation or transrepression, are often contained within separable domains. DNA-binding domains tend to be particularly well conserved and can be used as the basis for a classification that reflects phylogenetic relationships. Transcription factors with the same basic design in their interaction wit...
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ژورنال
عنوان ژورنال: Insect Biochemistry and Molecular Biology
سال: 2007
ISSN: 0965-1748
DOI: 10.1016/j.ibmb.2007.05.008